I kinda like Holmes by SD in this one, but not with any certainty. Lewis' jab could be taken away and he usually reverted to brawling when it was......I think Holmes would do pretty well both ways. The scale of the size disparity might be bigger than Im envisioning though.
I favour Holmes, but Id give Lewis a better shot than many. I could certainly see him winning, even if I figure Holmes the significantly better boxer of the two, which was a natural style of both men.