It's a fun fight to think about, Mosley is not shot like Oscar and it puts another Golden Boy fighter in there to get revenge.
First Shane would have to get past Margarito which is very unlikely. I don't see Manny facing a guy coming of a loss when there are better fights out there for him. If Mosley wins though, it would certainly be a great fight to make.
Mosley has even less head movement than Oscar. I think Mosley would take a few trips to the canvas before he was eventually stopped.
......... Mosley is a very tough fighter but to be honest I think he has serious problems pulling the trigger these days. He had all kinds of openings against Mayorga that he couldn't capitalize on. Mosley is about done IMO.
Although I didn't see the Pac-DLH fight, I have a hard time believing Oscar looked worse in his fight than Mosley did against Mayorga. If he actually did, I still don't think Shane has enough left to think he should challenge Manny. Too bad Manny wasn't around when Shane was still sugary because that would have been an awesome fucking fight.