I don't think any heavyweight "fucks Holyfield up", at least not a prime Holyfield. It would be really competitive.
Holy would get fucked up down the stretch. Louis' heavy jab would consistently bust him in the face and throw off his bouncing rhythm, and in close he'd get chewed up by simply the best short puncher that ever lived. I don't think Holy sees the distance.
Lesser fighters than Holyfield were able to give Louis hell. Again, I think Joe pulls it out in the end but it will be give and take for the most part.
It would be back and forth for awhile. But Louis' offense would take over at some point. Only bad matchups for Louis I see are Tyson, Foreman, and Lewis, as I think their size and power would be too much for Joe. But prime Holy was only weighing like 205-210 and wasn't a devastating puncher. I think his style is made for Louis.
Louis is one of my favorites to watch and I know he beat Buddy Baer and Carnera to prove that size doesn't matter in boxing at all. Still, seeing 175 lbs Billy Conn slug it out evenly with him makes me wonder